Although the cause of IBS is not well understood, it is characterized by spasming in the colon that takes place in response to everyday activities like eating, explain experts at Mount Sinai. As a result, people with IBS experience changes in their bowel movements that often present in the form of diarrhea or constipation. Although no relationship has been found between IBS and alternate inflammatory bowel diseases (IBD), those with IBD — which includes Crohn’s disease and ulcerative colitis — may also be susceptible to IBS.
Because non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen reduce pain and inflammation, they are thought to be helpful in relieving IBS symptoms. Yet researchers from the 2017 scientific review say the evidence to support this is lacking. Instead, using NSAIDs on an ongoing basis has been linked with chronic constipation, as well as weakened intestinal absorption in patients with IBS. Other gastrointestinal side effects associated with NSAID use include ulcers, narrowing of the intestines, rectal inflammation, and more.
